Authors: Ortiz, R. A. M.¹; Calafatti, S. A.¹; Corazzi, A.¹; Souza, J. M.¹; Deguer, M.¹; De Souza, C. A. F.²; Marchioretto, M. A. M.¹; Bernasconi, G.¹; Ferraz, J. G. P.³; Pedrazzoli, J.¹

Source: Alimentary Pharmacology & Therapeutics, Volume 16, Number 6, June 2002 , pp. 1163-1170(8)

Publisher: Wiley-Blackwell

Abstract:

Background:

The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim:

The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods:

Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results:

Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC_{0-2 h}. Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion:

Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen.

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2036.2002.01262.x

Affiliations: 1: Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil, 2: Department of Pathology, São Francisco University Medical School, Bragança Paulista, SP, Brazil, 3: Discipline of Gastroenterology, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Brazil

Publication date: 2002-06-01

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• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: Ortiz, R. A. M. ;  Calafatti, S. A. ;  Corazzi, A. ;  Souza, J. M. ;  Deguer, M. ;  De Souza, C. A. F. ;  Marchioretto, M. A. M. ;  Bernasconi, G. ;  Ferraz, J. G. P. ;  Pedrazzoli, J.

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