Authors: Katsube, T.; Adachi, K.; Kawamura, A.; Amano, K.; Uchida, Y.; Watanabe, M.; Kinoshita, Y.

Source: Alimentary Pharmacology & Therapeutics, Volume 14, Number 8, August 2000 , pp. 1049-1056(8)

Publisher: Wiley-Blackwell

Abstract:

Background: 

Nocturnal gastric acid breakthrough is defined as night-time periods when gastrin pH falls below 4.0 for greater than 1h during administration of a proton pump inhibitor. This phenomenon is a serious problem for patients who require strict control of their gastric acid secretions. Aim: 

To investigate the prevalence of nocturnal gastric acid breakthrough in Japanese subjects during administration of rabeprazole, and to clarify the relationship between Helicobacter pylori infection and nocturnal gastric acid breakthrough. Methods: 

Thirty-one normal male volunteers were examined by ambulatory 24 h gastric pH monitoring four times: without medication, after a morning or an evening dose of 20 mg rabeprazole, and after administration of an H₂-receptor antagonist at bedtime, in addition to the morning dose of rabeprazole. H. pylori infection was determined by the ¹³C-urea breath test and an assay for serum anti-H. pylori antibody. Result: 

Nocturnal gastric acid breakthrough was observed in 12 patients (39%) after the morning dose of 20 mg rabeprazole. In all cases, nocturnal gastric acid breakthrough was inhibited completely by administration of the H₂-receptor antagonist at bedtime. Only one patient with nocturnal gastric acid breakthrough had H. pylori infection. Conclusion: 

The absence of H. pylori infection appears to be closely related to the occurrence of nocturnal gastric acid breakthrough during dosing with a proton pump inhibitor.

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00799.x

Affiliations: 1: Department of Internal Medicine II, Shimane Medical University, Izumo, Japan

Publication date: 2000-08-01

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• In this Subject: Pathology ,  Pharmacology ,  Surgery ,  Therapeutics & Alternative Medicine
• By this author: Katsube, T. ;  Adachi, K. ;  Kawamura, A. ;  Amano, K. ;  Uchida, Y. ;  Watanabe, M. ;  Kinoshita, Y.

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