Authors: O'connor¹; McLoughlin¹; Kelly¹; Laundon¹; Cunnane²

Source: Alimentary Pharmacology & Therapeutics, Volume 12, Number 3, March 1998 , pp. 273-276(4)

Publisher: Wiley-Blackwell

Abstract:

Background:

Seven-day proton pump inhibitor triple therapy is currently the treatment of choice for Helicobacter pylori infection. It is unclear whether triple therapy for less than 7 days might preserve efficacy while at the same time improving patient acceptability and compliance. Aim:

To evaluate the Helicobactericidal efficacy, ulcer healing capacity and patient acceptability of a 5-day lansoprazole-based triple therapy regimen. Methods:

Sixty-nine consecutive patients with H. pylori-positive peptic ulcer received lansoprazole 30 mg twice daily in combination with metronidazole 400 mg twice daily and clarithromycin 250 mg twice daily for 5 days. Ulcer healing medication was not continued after the 5-day regimen. H. pylori status was assessed before and at least 4 weeks after therapy by rapid urease test and histology. Adverse events and compliance were assessed by direct questioning. Results:

All 69 patients attended for repeat endoscopy and 63 were H. pylori-negative after therapy giving a cure rate of 91% (95% Cl: 85-98%). Of the 59 patients with active ulcers, 58 were healed at repeat endoscopy giving an ulcer healing rate of 98% (95% Cl: 92-100%). All patients fully complied with therapy and mild adverse events, mainly gastrointestinal, were reported by 11 patients (16%). Conclusions:

Five-day lansoprazole triple therapy is an effective regimen for H. pylori infection which combines a high cure rate and ulcer healing efficacy with the advantages of excellent patient acceptability and compliance.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2036.1998.00290.x

Affiliations: 1: Department of Medicine, General Hospital, Tullamore, Co. Offaly, Ireland, 2: Department of Pathology, General Hospital, Tullamore, Co. Offaly, Ireland

Publication date: 1998-03-01

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