IngentaConnect The effects of low doses of ranitidine on intragastric acidity in...

Abstract:

Background:

H₂-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. Aim:

To determine the effects of single low doses of ranitidine on intragastric acidity. Methods:

Intragastric pH was measured for 9 h after lunch in five studies involving 24 healthy male volunteers. Antacid was given to all subjects on day 1. They then received single oral doses of a study drug 45 min after lunch on four separate occasions: placebo and either ranitidine 25 mg, 75 mg or 125 mg were given double-blind according to a predetermined randomization schedule. Results:

During both of the post-dosing time periods (0-5 h and 5-9 h) there were significant decreases in integrated intragastric acidity for each ranitidine dose compared with placebo (P < 0.0001). There was a significant linear relationship between dose and integrated intragastric acidity with a greater decrease in acidity with increasing ranitidine doses (P < 0.0001). Compared with placebo, time with pH > 3 was significantly greater for ranitidine 75 mg and 125 mg (P < 0.001), but not ranitidine 25 mg. Results with the antacid were similar to placebo. Conclusions:

Using low doses of ranitidine (25, 75 or 125 mg) there was a dose-related decrease in intragastric acidity for 9 h after dosing. A single dose of antacid did not decrease intragastric acidity significantly.

Document Type: Original article

DOI: 10.1046/j.1365-2036.1998.00307.x

Affiliations: 1: Royal Free Hospital School of Medicine, London, UK, 2: Glaxo Wellcome Research & Development, Greenford, UK

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The effects of low doses of ranitidine on intragastric acidity in healthy men