@article {Wyeth:March 1998:0953-0673:255,
author = "Wyeth,",
author = "Pounder,",
author = "Sercombe,",
author = "Snell,",
title = "The effects of low doses of ranitidine on intragastric acidity in healthy men",
journal = "Alimentary Pharmacology & Therapeutics",
volume = "12",
year = "March 1998",
abstract = "Background: H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. Aim: To determine the effects of single low doses of ranitidine on intragastric acidity. Methods: Intragastric pH was measured for 9 h after lunch in five studies involving 24 healthy male volunteers. Antacid was given to all subjects on day 1. They then received single oral doses of a study drug 45 min after lunch on four separate occasions: placebo and either ranitidine 25 mg, 75 mg or 125 mg were given double-blind according to a predetermined randomization schedule. Results: During both of the post-dosing time periods (0-5 h and 5-9 h) there were significant decreases in integrated intragastric acidity for each ranitidine dose compared with placebo (P < 0.0001). There was a significant linear relationship between dose and integrated intragastric acidity with a greater decrease in acidity with increasing ranitidine doses (P < 0.0001). Compared with placebo, time with pH > 3 was significantly greater for ranitidine 75 mg and 125 mg (P < 0.001), but not ranitidine 25 mg. Results with the antacid were similar to placebo. Conclusions: Using low doses of ranitidine (25, 75 or 125 mg) there was a dose-related decrease in intragastric acidity for 9 h after dosing. A single dose of antacid did not decrease intragastric acidity significantly.",
pages = "255-261(7)",
url = "http://www.ingentaconnect.com/content/bsc/apt/1998/00000012/00000003/art00009"
doi = "doi:10.1046/j.1365-2036.1998.00307.x"
}