Authors: Bardhan¹; Morton¹; Slater¹; Perry¹; Cherian¹; Jones¹; Brookes¹; Thompson¹; Morris¹; McCaldin²

Source: Alimentary Pharmacology & Therapeutics, Volume 12, Number 2, February 1998 , pp. 185-189(5)

Publisher: Wiley-Blackwell

Abstract:

Aim:

To investigate the efficacy of a short course of pantoprazole-based triple therapy in Helicobater pylori eradication in a single-centre pilot study. Methods:

Patients with active or healed duodenal ulcer or with gastric erosions or gastritis, all of whom were H. pylori-positive, received 10 days of twice-daily open treatment with pantoprazole 40 mg, plus clarithromycin 250 mg and tinidazole 500 mg. H. pylori was assessed at entry and 28-35 days after the end of treatment by rapid urease test (at entry only), culture and antimicrobial sensitivity, histology and ¹³C urea breath test. The criterion for eradication was a negative result in all three tests. Results:

Seventy patients were treated, of whom four were excluded from analysis due to major deviations from the study protocol. Eradication of H. pylori was achieved in 57/66 patients (per protocol analysis 86% (95% CI: 78-95%)) and was higher in patients with organisms sensitive to nitroimidazole before treatment (sensitive: 47/53 (89%), insensitive: 10/13 (77%)). There was marked reduction in acute gastritis throughout the stomach while chronic gastritis decreased only in the corpus. Healing was achieved in all 24 patients with active duodenal ulcer. Treatment was complied with; only one patient missed one of the 20 doses. Adverse events were of mild or moderate intensity and did not require withdrawal from treatment. Conclusion:

A short course of pantoprazole-based triple therapy is well tolerated and effective in eradicating H. pylori.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2036.1998.00276.x

Affiliations: 1: Rotherham General Hospital NHS Trust, Rotherham, UK, 2: Scicom, Indian Queens, Cornwall, UK

Publication date: 1998-02-01

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