@article {Brown:February 1998:0953-0673:141,
	author = "Brown,",
	author = "James,",
	title = "Omeprazole, ranitidine and cimetidine have no effect on peak blood ethanol concentrations, first pass metabolism or area under the timeethanol curve under real-life drinking conditions",
	journal = "Alimentary Pharmacology & Therapeutics",
	volume = "12",
	year = "February 1998",
	abstract = "Background: <P></P>Considerable controversy persists over the influence of H<SUB>2</SUB>-receptor antagonists on the first pass clearance of ethanol. The majority of previously published studies have studied the effects of the drugs on low-dose ethanol in the fasting state. We elected to study the possible interaction under simulated real-life conditions. Methods: <P></P>Twenty-three volunteers were given 0.6&#8201;g/kg body weight ethanol in the form of 4.8% beer following a standardized meal. Blood ethanol levels were measured over the next 3&#8201;h. Studies were repeated using ethanol administered as an intravenous infusion while subjects consumed the same volume of de-alcoholized beer. The effects of a minimum of 2&#8201;weeks of dosing with cimetidine, ranitidine and omeprazole were examined. Results: <P></P>Following food, and with ethanol taken in the form of beer, mean first pass metabolism of ethanol was 58% (range 34-78%). No statistically significant difference was found following drug treatment in either percentage first pass metabolism, peak blood ethanol concentration or area under the time-blood ethanol curve. Conclusion: <P></P>Under these `real-life' conditions, the concomitant administration of cimetidine, ranitidine or omeprazole is unlikely to have significant physical, social or forensic implications, since they do not significantly change ethanol elimination.",
	pages = "141-145(5)",
	url = "http://www.ingentaconnect.com/content/bsc/apt/1998/00000012/00000002/art00004"
	doi = "doi:10.1046/j.1365-2036.1998.00281.x"
}