Authors: Bate¹; Green²; Axon³; Tildesley³; Murray⁴; Owen⁵; Emmas⁵; Taylor⁵

Source: Alimentary Pharmacology & Therapeutics, Volume 12, Number 1, January 1998 , pp. 41-47(7)

Publisher: Wiley-Blackwell

Abstract:

Background:

There is documentation of the long-term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastro-oesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long-term use of cimetidine in GERD patients. Methods:

One hundred and fifty-six patients (100 male) who previously had symptomatic non-ulcerative oesophagitis (81%) or symptoms without oesophagitis (19%), were recruited. All patients were in symptomatic remission following 4 weeks of omeprazole 20 mg o.d. or cimetidine 400 mg q.d.s. and, if required, a further 4 weeks of omeprazole 20 mg o.d. Patients were randomized to receive, double-blind, either omeprazole 10 mg o.m. (n = 77) or cimetidine 800 mg nocte (n = 79) for 24 weeks. Results:

A greater proportion of patients receiving omeprazole, compared with cimetidine, were in symptomatic remission after 12 (69 vs. 27%) and 24 weeks (60 vs. 24%) (each P < 0.0001). The median time to symptomatic relapse was longer for patients receiving omeprazole (169 vs. 15 days) (P = 0.0001). Of patients leaving the study in symptomatic remission, a greater proportion receiving omeprazole, compared with cimetidine, was free of oesophagitis (84 vs. 53%) (P < 0.05). Conclusion:

Omeprazole 10 mg o.m. is more effective than cimetidine 800 mg nocte in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophagitis.

Document Type: Original article

DOI: http://dx.doi.org/10.1046/j.1365-2036.1998.00272.x

Affiliations: 1: Royal Albert Edward Infirmary, Wigan, UK, 2: General Hospital, Stoke-on-Trent, UK, 3: General Hospital, Hartlepool, UK, 4: Ninewells Hospital, Dundee, UK, 5: Clinical Research Operations Department, Astra Pharmaceuticals Ltd, Kings Langley, UK

Publication date: 1998-01-01

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