Morning versus evening dosing of lansoprazole 30 mg daily on twenty-four-hour intragastric acidity in healthy subjects

Authors: Fraser, A.G.; Sawyerr, A.M.; Hudson, M.; Smith, M.S.H.; Pounder, R.E.

Source: Alimentary Pharmacology & Therapeutics, Volume 10, Number 4, 1 August 1996 , pp. 523-2813(2291)

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Abstract:

Background: Morning dosing is usually recommended with proton pump inhibitors, but there are few data from 24-h intragastric acidity studies comparing times of dosing.

Methods: A double-blind, placebo-controlled study was performed on the seventh day of dosing to compare the effects of lansoprazole 30 mg given either in the morning or evening on 24-h intragastric acidity in 32 healthy volunteers.

Results: The median integrated 24-h intragastric acidity on the seventh day of morning dosing with lansoprazole 30 mg was decreased to 36% of the placebo value, compared with 42% for evening dosing. For each daytime meal-related interval, morning dosing was significantly more effective for controlling acidity, but there was no significant difference between the regimens during the night interval (23.00-08.00 h).

Conclusions: These data favour morning dosing of lansoprazole 30 mg for routine use, but patients with mainly nocturnal symptoms may be best treated by evening dosing.

Document Type: Research article

Affiliations: 1: University Department of Medicine, Royal Free Hospital School of Medicine, London, UK

Publication date: 1996-08-01