Skip to main content

Impact of age and sex on carotid and peripheral arterial wall thickness in humans

Buy Article:

$43.00 plus tax (Refund Policy)


Although previous studies have reported age‐related wall thickening in carotid arteries, it is not clear whether this is a systemic phenomenon which is also apparent in peripheral conduit arteries or whether conduit wall thickness (WT) changes occur to a similar degree in men and women.

To determine whether sex modifies the impact of ageing on WT or wall‐to‐lumen ratio (W:L) in atherosclerosis‐prone (i.e. carotid artery, femoral, superficial femoral, popliteal artery) and atherosclerosis‐resistant (i.e. brachial artery) conduit arteries.

We included 30 young (23 ± 2 year; 15M : 15F) and 31 older (70 ± 5 year; 18M : 13F) healthy subjects. High‐resolution ultrasound was used to measure diameter, WT and wall‐to‐lumen ratio (W/L) in all arteries.

Older subjects had increased WT and W/L in the carotid, femoral, superficial femoral, popliteal and brachial arteries (all P < 0.05). Compared with women, men demonstrated larger diameter and WT (both P < 0.01) across all arteries. Sex did not impact upon age‐related changes in WT or W/L (P = 0.39 and 0.43 respectively).

Our data suggest that age‐related wall thickening, evident in the carotid artery, is also apparent in the arteries of the upper and lower limbs. The impact of age on wall thickening did not differ between men and women. These data support the presence of systemic increases in WT and W/L with age in apparently healthy humans, independent of sex.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: 01 December 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more