Cross-talk between macro- and microcirculation
Physiologically, macro- and microcirculation differ markedly as macrocirculation deals with pulsatile pressure and flow and microcirculation with steady pressure and flow. Various such haemodynamic aspects correspond to a large heterogeneity in the structure and function of the vascular tree. In the past, diseases such as hypertension and diabetes mellitus were classified on the basis of the structure and function of small and large arteries. The purpose of this paper is to review the cross-talk between the micro- and macrocirculation. We shall discuss this cross-talk from the perspective of the development, physiology and pathology of the entire arterial tree.
Document Type: Research Article
Affiliations: Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, the Netherlands
Publication date: April 1, 2010