Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damage
Authors: Voronina, S.; Sherwood, M.; Barrow, S.; Dolman, N.; Conant, A.; Tepikin, A.
Source: Acta Physiologica, Volume 195, Number 1, January 2009 , pp. 161-169(9)
Ca2+ is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca2+ signalling and homeostasis. Downstream effects of Ca2+ signalling have been and continue to be an important research avenue. The primary functions regulated by Ca2+ in pancreatic acinar cells – exocytotic secretion and fluid secretion – have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca2+ in cellular pathology and the related question of the interplay between Ca2+ signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review.
Document Type: Research Article
Publication date: January 1, 2009