Neuronismo y reticulismo: neuronal–glial circuits unify the reticular and neuronal theories of brain organization
The neuronal doctrine, which shaped the development of neuroscience, was born from a long-lasting struggle between reticularists, who assumed internal continuity of neural networks and neuronists, who defined the brain as a network of physically separated cellular entities, defined as neurones. Modern views regard the brain as a complex of constantly interacting cellular circuits, represented by neuronal networks embedded into internally connected astroglial syncytium. The neuronal–glial circuits endowed with distinct signalling cascades form a ‘diffuse nervous net’ suggested by Golgi, where millions of synapses belonging to very different neurones are integrated first into neuronal–glial–vascular units and then into more complex structures connected through glial syncytium. These many levels of integration, both morphological and functional, presented by neuronal–glial circuitry ensure the spatial and temporal multiplication of brain cognitive power.