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Measuring diffusion parameters in the brain: comparing the real-time iontophoretic method and diffusion-weighted magnetic resonance

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Abstract:

Abstract

The extracellular space (ECS) diffusion parameters influence the movement of ions, neuroactive substances, hormones and metabolites in the nervous tissue. They also affect extrasynaptic transmission, a mode of signal transmission dependent solely on diffusion. This review compares in detail two methods for studying diffusion in the brain: the real-time iontophoretic tetramethylammonium method for ECS volume fraction and tortuosity measurements and diffusion weighted-magnetic resonance imaging for measuring the apparent diffusion coefficient of water. The results obtained using both methods under physiological conditions (post-natal development, ageing) or in pathologies (brain injury, ischaemia) and their similarities and differences are discussed.

Keywords: apparent diffusion coefficient; diffusion anisotropy; extracellular matrix; extracellular space; extrasynaptic transmission; tortuosity; volume fraction

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1748-1716.2008.01924.x

Publication date: January 1, 2009

bsc/aps/2009/00000195/00000001/art00011
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