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The ICln interactome

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The many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one-protein–one-function base. Therefore, the study of the interactome of the different proteins is of utmost importance. Here, we describe the present knowledge of the ICln interactome. ICln is a protein, we cloned and whose function was reported to be as divers as (i) ion permeation, (ii) cytoskeletal organization, and (iii) RNA processing. The role of ICln in these different functional modules can be described best as being a ‘connector hub’ with ‘date hub’ function.

Keywords: ICln; RNA-processing; interactomics; ion channels; methylosome; proteomics; volume regulation

Document Type: Research Article


Affiliations: 1: Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria 2: Department of Biomolecular Sciences and Biotechnology, Università degli Studi di Milano, Milan, Italy 3: CIMAINA, Department of Physics, University of Milan, Milan, Italy 4: Institute of Physiology Paracelsus Private Medical University, Salzburg, Austria

Publication date: May 1, 2006

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