Skip to main content

Effects of acute hypobaric hypoxia on regional cerebral blood flow distribution: a Single Photon Emission Computed Tomography study in humans

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Single Photon Emission Computed Tomography (SPECT) and radiopharmaceutical stabilizing agents allowed us to investigate regional cerebral blood flow (CBF) distribution in six resting healthy subjects during acute laboratory hypobaric hypoxic conditions. In the hypobaric experiment stabilized 99mTc-D,L-hexamethyl-propylene amine oxime was injected 40 min after reaching hypoxic conditions corresponding to an altitude of 5500 m above sea level. Arterial blood sample was taken after five additional minutes. Mean arterial oxygen pressure and haemoglobin saturation were 28 mmHg and 56%, respectively. The control experiment was performed similarly, apart from barometric pressure and blood gas analysis. We analysed CBF distribution in 12 regions of functional interest bilaterally in frontal, parietal, temporal, occipital cortex, in the hippocampus, in the basal ganglia and other central structures of brain. No overall effect of hypoxia on normalized regional CBF distribution in the considered regions was found. Motor cortex (Brodmann 4) and basal ganglia were the only regions in which hypobaric hypoxia significantly increased relative distribution of the radiopharmaceutical [F(1,5)=18.30; P < 0.008 and F(1,5)=10.85; P < 0.022, respectively]. Despite severe hypoxia, we did not observe any major regional CBF redistribution. We found a small relative increase in blood flow to the motor cortex and the basal ganglia, at rest after 40 min of hypobaric hypoxia, suggesting a preferential compensatory mechanism of these functional regions of brain.

Keywords: Single Photon Emission Computed Tomography; basal ganglia; hypobaric hypoxia; motor cortex; regional cerebral blood flow

Document Type: Research Article

DOI: https://doi.org/10.1046/j.1365-201x.2000.00649.x

Affiliations: 1: Section of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden 2: Department of Anaesthesiology, Karolinska Hospital, Stockholm, Sweden 3: Institute of Psychology, CNR, Rome, Italy 4: Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden

Publication date: 2000-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more