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Further evidence for the existence of a volume-activated taurine efflux pathway in rat mammary tissue independent from volume-sensitive Cl channels

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The effect of cell-swelling, induced by a hyposmotic shock, on the fractional loss of taurine, D-aspartate and iodide from lactating rat mammary tissue explants has been examined. In paired experiments, cell-swelling markedly increased the fractional efflux of taurine but not that of D-aspartate. Similarly, in paired experiments, a hyposmotic challenge stimulated taurine release but not iodide efflux. The results suggest that volume-activated taurine efflux from mammary tissue explants is via a pathway independent from volume-sensitive anion channels. It is apparent that the volume-activated taurine efflux pathway in mammary tissue is not the volume-sensitive organic osmolyte–anion channel which has been described in other cells. Therefore, the results of this study together with others in the literature constitute prima facie evidence for the existence of more than one type of swelling-activated pathway which accepts taurine as a substrate.
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Keywords: mammary; taurine; volume-activated transport

Document Type: Research Article

Affiliations: Hannah Research Institute, Ayr, Scotland, UK

Publication date: 2000-02-01

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