Leflunomide-induced nodulosis in a case of Rheumatoid arthritis

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We herein report accelerated nodulosis in a 49-year-old woman with rheumatoid arthritis who was treated with methotrexate and leflunomide. She developed multiple pulmonary and subcutaneous nodules 2 years after the addition of leflunomide to methotrexate. The nodules developed when the rheumatoid arthritis was in remission. The pulmonary nodules regressed following the institution of hydroxychloroquine after stopping leflunomide.

Keywords: leflunomide; nodulosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1479-8077.2007.00297.x

Publication date: September 1, 2007

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