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Leflunomide-induced nodulosis in a case of Rheumatoid arthritis

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We herein report accelerated nodulosis in a 49-year-old woman with rheumatoid arthritis who was treated with methotrexate and leflunomide. She developed multiple pulmonary and subcutaneous nodules 2 years after the addition of leflunomide to methotrexate. The nodules developed when the rheumatoid arthritis was in remission. The pulmonary nodules regressed following the institution of hydroxychloroquine after stopping leflunomide.
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Keywords: leflunomide; nodulosis

Document Type: Research Article

Publication date: 2007-09-01

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