Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Abstract

Aim: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, KATP channel-mediated relaxation responses in the aortas and mesenteric arteries, KATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high-fat diet. KATP channel-mediated relaxation responses, currents, and KATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.

Keywords: ATP-sensitive potassium channel; aorta; electrophysiology; mesenteric artery; obesity-hypertension

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1745-7254.2008.00810.x

Affiliations: 1: Department of Cardiology, The First Affiliated Hospital of Xi-an Jiaotong University School of Medicine, Xi-an 710061, China 2: Department of Pharmacology, Xi'an Jiaotong University School of Medicine, Xi-an 710061, China

Publication date: October 1, 2008

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more