Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients

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Abstract:

Abstract

Aim: To detect 388G>A and 521T>C variant alleles in the organic anion transporting polypeptide-1B1 (OATP1B1, encoding gene SLCO1B1) gene. Methods: One hundred and eleven healthy volunteers were screened for OATP1B1 alleles in our study. PCR-restriction fragment length polymorphism was used to identify the 388G>A polymorphism and a 1-step tetra-primer method was developed for the determination of 521T>C mutation. Results: The frequencies of the 388G>A and 521T>C variant alleles in the Chinese population were 73.4% and 14.0%, respectively. The frequencies of the SLCO1B1*1b and *15 haplotypes were 59.9% and 14.0%, respectively. Conclusion: The SLCO1B1*1b and SLCO1B1*15 variants are relatively common in the Chinese population. Their frequencies are similar to that in the Japanese, but significantly different from that in Caucasians and blacks.

Keywords: 388G>A; 521T>C; Chinese patients; genotyping; organic anion transporting polypeptide-1B1

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1745-7254.2007.00643.x

Affiliations: 1: Department of Epidemic and Health Statistics, School of Public Health, Central South University, Changsha 410078, China 2: Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China 3: Affiliated Xiangya Hospital of Central South University, Changsha 410078, China

Publication date: October 1, 2007

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