@article {MA:November 2006:1671-4083:1423,
	author = "MA, Shi-ping",
	author = "REN, Lei-ming",
	author = "ZHAO, Ding",
	author = "ZHU, Zhong-ning",
	author = "WANG, Miao",
	author = "LU, Hai-gang",
	author = "DUAN, Li-hua",
	title = "Chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats",
	journal = "Acta Pharmacologica Sinica",
	volume = "27",
	year = "November 2006",
	abstract = "<P></P><B>Aim:</B> To study chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats. <B>Methods:</B> In anesthetized rats, the carotid blood pressure, left ventricular pressure of the heart and the urinary bladder pressure were recorded. <B>Results:</B> Administration of <I>S</I>-doxazosin at 0.25, 2.5, 25, and 250 nmol&#47;kg iv produced a dose-dependent decrease in blood pressure, but its depressor effect was significantly weaker than that induced by <I>R</I>-doxazosin and racemic-doxazosin (rac-doxazosin), and the ED<SUB>30</SUB> values (producing a 30&#37; decrease in mean arterial pressure) of <I>R</I>-doxazosin, rac-doxazosin and <I>S</I>-doxazosinwere 15.64,45.93, and 128.81, respectively. Rac-doxazosin and its enantiomers administered cumulatively in anesthetized rats induced a dose-dependent decrease in the left ventricular systolic pressure and &#177;d<I>p</I>&#47;d<I>t</I><SUB>max</SUB>, and the potency order of the 3 agents was <I>R</I>-doxazosin &#62;rac-doxazosin &#62;<I>S</I>-doxazosin. Rac-doxazosin and its enantiomers decreased the vesical micturition pressure dose-dependently at 2.5,25, and 250 nmol&#47;kg, and the inhibitory potency among the 3 agents was not significantly different. <B>Conclusion:</B><I>S</I>-doxazosin decreases the carotid blood pressure and left ventricular pressure of the heart less than <I>R</I>-doxazosin and rac-doxazosin, but its effect on the vesical micturition pressure is similar to <I>R</I>-doxazosin and rac-doxazosin, indicating that <I>S</I>-doxazosin has chiral selectivity between cardiovascular system and urinary system in anesthetized rats.",
	pages = "1423-1430(8)",
	url = "http://www.ingentaconnect.com/content/bsc/aphs/2006/00000027/00000011/art00006"
	doi = "doi:10.1111/j.1745-7254.2006.00443.x"
}