In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor

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Abstract:

Abstract

Aim: To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time. Methods: Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method. Results: The average diameter of the gelatin particle-PLGA microsphere composite was 5–18 um, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation. Conclusion: A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.

Keywords: basic fibroblast growth factor; delayed-action preparations; gelatin; microsphere; poly(lactic-co-glycolic acid)

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1745-7254.2006.00337.x

Affiliations: 1: Key Laboratory for Biomechanical and Tissue Engineering, State Ministry of Education, College of Bioengineerin, Chongqing University, Chongqing 400030, China 2: Gene Medicine Engineering Research Center, Jinan University, Guangzhou 510632, China

Publication date: June 1, 2006

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