Clinical Experience with Molecular Adsorbent Recirculating System (MARS) in Patients with Drug-induced Liver Failure
Authors: Xin-min Zhou1; Ji-yan Miao1; Yan Yang1; Ling Zhao1; Xin Wang1; Li Xu1; Jie Ding1; Kai-chun Wu1; Dai-ming Fan; Min-min Wang2
Source: Artificial Organs, Volume 28, Number 5, May 2004 , pp. 483-486(4)
Publisher: Blackwell Publishing
Abstract:
: The molecular adsorbent recirculating system (MARS) is a novel extracorporeal technique for liver support. We report the clinical results in a group of fourteen patients with drug-induced liver failure. Fourteen patients, aged 2283 years, with acute or subacute liver failure [mean ChildTurcottePugh (CTP) score 11 (range 815)] due to the intake of various drugs (diet pill overdose2; Chinese traditional medicine (CTM)4; antibiotic, paracetamol, tuberculostatic, or vasodilator abuse8) were treated with one to seven sessions of MARS. Beneficial effects such as the improvement of encephalopathy and prothrombin activity, as well as a reduction of bilirubin and ammonia were recorded during MARS treatments. Thirteen out of fourteen patients survived the hospitalization (93%), and two of the discharged patients died during the follow-up of 612 months. The overall survival rate was about 79%. MARS therapy can contribute to the improved treatment of drug-induced liver failure patients.Keywords: Artificial liver; Molecular adsorbent recirculating system; Drug induced; Liver failure
Document Type: Research article
DOI: 10.1111/j.1525-1594.2004.00010.x
Affiliations: 1: Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian, China 2: Therapeutic Blood Purification Research Center, University of Rostock, Germany

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