Optimal remifentanil dosage for providing excellent intubating conditions when co-administered with a single standard dose of propofol

Authors: Bouvet, L.; Stoian, A.; Rimmelé, T.; Allaouchiche, B.; Chassard, D.; Boselli, E.

Source: Anaesthesia, Volume 64, Number 7, July 2009 , pp. 719-726(8)

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

Summary

This dose-response study aimed to determine the dose of remifentanil combined with propofol 2.5 mg.kg⁻¹ which provided excellent intubation conditions in 95% of patients. Ninety premedicated female ASA 1 and 2 patients were randomly allocated to five remifentanil dose groups (1, 2, 3, 4 or 5 μg.kg⁻¹). Induction of anaesthesia was performed with a blinded dose of remifentanil infused over 60 s simultaneously co-administered with propofol 2.5 mg.kg⁻¹ infused over 45 s. Tracheal intubation was attempted 150 s after the beginning of induction. Intubating conditions were assessed with the Copenhagen score. A probit analysis was performed to calculate the intubating efficient doses (IED) of remifentanil in 95% of patients (IED₉₅). Our data revealed that the IED₉₅ of remifentanil was 4.0 (95% CI: 3.4-5.6) μg.kg⁻¹, which was associated with a maximum decrease in heart rate and mean arterial pressure of < 30%, a finding which also applied to the other groups.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2044.2009.05916.x

Publication date: 2009-07-01