Authors: Turan, A.¹; Apfel, C. C.²; Kumpch, M.³; Danzeisen, O.⁴; Eberhart, L. H. J.⁵; Forst, H.⁶; Heringhaus, C.⁴; Isselhorst, C.⁷; Trenkler, S.⁸; Trick, M.⁹; Vedder, I.¹⁰; Kerger, H.¹¹

Source: Anaesthesia, Volume 61, Number 7, July 2006 , pp. 628-633(6)

Publisher: Wiley-Blackwell

Abstract:

Summary

High intra-operative oxygen concentration reportedly reduces postoperative nausea and vomiting (PONV), but recent data are conflicting. Therefore, we tested whether the effectiveness of supplemental oxygen depends on the endpoint (nausea vs. vomiting), observation interval (early vs. late) or surgical field (abdominal vs. non-abdominal). We randomly assigned 560 adult patients undergoing various elective procedures with a PONV risk of at least 40% to intra-operative 80% (supplemental) or 30% oxygen (control). Potential confounding factors were similar between groups. Incidences of nausea were similar in the groups during early (12% (supplemental) vs. 10% (control), p = 0.43) and late intervals, 26%vs. 20%, p = 0.09, as were the incidences of vomiting (early: 2%vs. 3%, p = 0.40; late: 8%vs. 9%, p = 0.75). Supplemental oxygen was no more effective at reducing PONV in abdominal (40%vs. 31%, p = 0.37) than in non-abdominal surgery (25%vs. 21%, p = 0.368). Thus, supplemental oxygen was unable to reduce PONV independent of the endpoint, observational period or site of surgery.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2044.2006.04703.x

Affiliations: 1:  Assistant Professor, Department of Anaesthesiology, Trakya University, Turkey, and theoutcomes researchInstitute and Department of Anaesthesiology & Perioperative Medicine, University of Louisville, Louisville, Kentucky, USA 2:  Associate Professor, Department of Anaesthesia and Perioperative Care, University of California at San Francisco (UCSF), San Francisco, California, USA andoutcomes researchInstitute, University of Louisville, Louisville, KY, USA 3:  Staff Anaesthesiologist, Institut fuer Anaesthesiologie und Notfallmedizin, Westpfalz-Klinikum, Kaiserslautern, Germany 4:  Staff Anaesthesiologist, Department of Anaesthesiology, University of Freiburg, Freiburg, Germany 5:  Staff Anaesthesiologist, Department of Anaesthesiology, University of Marburg, Marburg, Germany 6:  Professor of Anaesthesiology and Chair, Department of Anaesthesiology and Surgical Critical Care, Zentralklinikum Augsburg, Germany 7:  Staff Anaesthesiologist, Department of Anaesthesiology, Klinikum Mannheim der Universitaet Heidelberg, Mannheim, Germany 8:  Professor of Anaesthesiology and Chair, Department of Anaesthesiology, Reiman University Hospital, Presov, Slovakia 9:  Staff Anaesthesiologist, Department of Anaesthesiology, Universitaetsklinik Tuebingen, Tuebingen, Germany 10:  Klinik fuer Anaesthesiologie und Operative Intensivmedizin, von Bodelschwinghsche Anstalten Bethel, Bielefeld, Germany 11:  Professor, Department of Anaesthesiology & Operative Critical Care Medicine, University Hospital of Mannheim, Mannheim, Germany, and Director, Department of Anaesthesiology & Intensive Care Medicine, Evangelian Deacony Hospital, Freiburg, Germany

Publication date: 2006-07-01

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• By this author: Turan, A. ;  Apfel, C. C. ;  Kumpch, M. ;  Danzeisen, O. ;  Eberhart, L. H. J. ;  Forst, H. ;  Heringhaus, C. ;  Isselhorst, C. ;  Trenkler, S. ;  Trick, M. ;  Vedder, I. ;  Kerger, H.

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