Reduction in protein S activity during normal pregnancy

Authors: KURASAWA, Gotaro¹; KOTANI, Kazuhiko²; ITO, Yuji¹; SAIGA, Kyoko²; IIJIMA, Kenji³

Source: Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 47, Number 3, June 2007 , pp. 213-215(3)

Publisher: Wiley-Blackwell

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

We investigated the serial changes in blood protein S (PS) and related proteins in 11 normal pregnant women. The PS activity decreased significantly in the third trimester and reached minimum levels (23.3%) one hour after delivery. Although the PS activity was reduced markedly below the normal limits, all the women delivered safely. The mechanisms that cause the reduction in PS activity and the clinically dangerous conditions involving PS activity during pregnancy warrant further investigation.

Keywords: C4bp; delivery; pregnancy; protein C; protein S

Document Type: Short communication

DOI: http://dx.doi.org/10.1111/j.1479-828X.2007.00720.x

Affiliations: 1: Departments of Obstetrics and Gynecology, Nishiagatsuma Welfare Hospital, Naganohara, Gunma, 2: Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, 3: Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan

Publication date: 2007-06-01