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Acute Tryptophan Depletion Alters Gastrointestinal and Anxiety Symptoms in Irritable Bowel Syndrome
Authors: Shufflebotham, Jonathan1; Hood, Sean2; Hendry, Julie3; Hince, Dana A.4; Morris, Kelly4; Nutt, David4; Probert, Chris1; Potokar, John4
Source: The American Journal of Gastroenterology, Volume 101, Number 11, November 2006 , pp. 2582-2587(6)
Publisher: Wiley-Blackwell
Abstract:
OBJECTIVES: To assess the effect of acute changes in serotonin (5-HT) synthesis using the acute tryptophan depletion (ATD) paradigm on gastrointestinal (GI) and mood symptoms in irritable bowel syndrome (IBS).METHODS: In a randomized double-blind crossover study, 29 subjects (18 patients with ROME II defined IBS and 11 age-matched controls) were studied under ATD and acute tryptophan increase (ATI) conditions. GI symptoms, mood and anxiety ratings, as well as plasma tryptophan concentrations were measured.RESULTS: Total (and free) plasma tryptophan concentrations decreased on the ATD day in patients (73%[82%]) and controls (73%[80%]), and increased on the ATI day in patients (59%[143%]) and controls (61%[381%]). Compared with the ATD day, IBS patients reported more GI symptoms on the ATI day at +210 (p < 0.001) and at +270 (p < 0.05) min post drink. IBS patients also reported less anxiety on the ATI day compared with the ATD day at +270 min (p < 0.001). ATD and ATI did not affect these ratings in control participants. IBS patients had a lower mood compared with controls (p < 0.05), but this did not differ between the ATI and ATD days in either group. CONCLUSIONS: IBS patients' GI and anxiety responses to changes in tryptophan load differ from controls. This suggests a difference in serotonergic functioning between these two groups and provides evidence to support the hypothesis that 5-HT dysfunction is involved in IBS.(Am J Gastroenterol 2006;101:2582-2587)Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1572-0241.2006.00811.x
Affiliations: 1: Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom 2: School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia 3: Bristol Royal Infirmary, Bristol, United Kingdom 4: Psychopharmacology Unit, University of Bristol, Bristol, United Kingdom
Publication date: 2006-11-01
- In this: publication
- By this: publisher
- In this Subject: Gastroenterology
- By this author: Shufflebotham, Jonathan ; Hood, Sean ; Hendry, Julie ; Hince, Dana A. ; Morris, Kelly ; Nutt, David ; Probert, Chris ; Potokar, John
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