Abdominal wall ulceration and mucinosis secondary to recombinant human interferon--1b

Authors: Wells, Jillian; Kossard, Steven; McGrath, Michael

Source: Australasian Journal of Dermatology, Volume 46, Number 3, August 2005 , pp. 202-204(3)

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Abstract:

SUMMARY

A 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon bgr

-1b subcutaneously for multiple sclerosis. Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis. Treatment with low-molecular-weight heparin followed by a heparinoid resulted in slow healing of the ulcers but also allowed the subcutaneous interferon injections to be continued.

Keywords: cutaneous infarction; low-molecular-weight heparin; multiple sclerosis

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-0960.2005.00181.x

Publication date: 2005-08-01