Molecular and cellular biology of basal cell carcinoma

$48.00 plus tax (Refund Policy)

Download / Buy Article:



The finding of mutations in the PTCH gene in both Gorlin's syndrome and sporadic basal cell carcinomas has significantly advanced our understanding of the molecular defects that lead to the formation of these tumours. Knowledge of the specific molecular and functional changes that have taken place in these tumours will help us devise more defined therapies, as well as give us a better understanding of normal molecular pathways involved in skin development and function. The following is a summary of our current understanding of the molecular and cellular biology of basal cell carcinoma.

Keywords: Bcl-2; Patched; TGF-β; apoptosis; p53

Document Type: Research Article


Affiliations: 1: Department of Dermatology, Princess Alexandra Hospital, Brisbane, Australia 2: Centre for Immunology and Cancer Research, Princess Alexandra Hospital, Brisbane, Australia

Publication date: November 1, 2002

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more