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Lung cancer patients with postoperative normalization of serum carcinoembryonic antigen level: Predictive factors for re-elevation

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Abstract:

Abstract Background: 

Postoperative normalization of serum carcinoembryonic antigen (CEA) level has been reported to be a favorable prognostic predictor in lung cancer. However, serum CEA levels of some patients’ groups re-elevate during their postoperative course. The aim of study was to find predictors of CEA re-elevation in patients with preoperative high and postoperative normal CEA. Methods: 

Sixty-one consecutive lung cancer patients with preoperative high serum CEA level (>5 ng/mL) and postoperative normal level were reviewed retrospectively. Among these patients, serum CEA levels of 23 patients re-elevated during their postoperative course. We compared patients with and without re-elevation of serum CEA levels. Results: 

The 5-year survival of patients with and without re-elevation of serum CEA level was 13.20% and 88.68%, respectively (P < 0.0001). There are significant differences in pN2 status and CEA level in pleural lavage fluid between patients with and without re-elevation of serum CEA level. Conclusions: 

Our results showed that pN2 status and lavage CEA level were related to the re-elevation of serum CEA level.

Keywords: lung cancer; postoperative normalization; re-elevation; serum carcinoembryonic antigen

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1743-7563.2006.00061.x

Publication date: September 1, 2006

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