Lung cancer patients with postoperative normalization of serum carcinoembryonic antigen level: Predictive factors for re-elevation
Postoperative normalization of serum carcinoembryonic antigen (CEA) level has been reported to be a favorable prognostic predictor in lung cancer. However, serum CEA levels of some patients’ groups re-elevate during their postoperative course. The aim of study was to find predictors of CEA re-elevation in patients with preoperative high and postoperative normal CEA. Methods:
Sixty-one consecutive lung cancer patients with preoperative high serum CEA level (>5 ng/mL) and postoperative normal level were reviewed retrospectively. Among these patients, serum CEA levels of 23 patients re-elevated during their postoperative course. We compared patients with and without re-elevation of serum CEA levels. Results:
The 5-year survival of patients with and without re-elevation of serum CEA level was 13.20% and 88.68%, respectively (P < 0.0001). There are significant differences in pN2 status and CEA level in pleural lavage fluid between patients with and without re-elevation of serum CEA level. Conclusions:
Our results showed that pN2 status and lavage CEA level were related to the re-elevation of serum CEA level.
Document Type: Research Article
Publication date: September 1, 2006