Skip to main content

Assessment of seminal plasma laminin in fertile and infertile men

Buy Article:

$43.00 plus tax (Refund Policy)


Aim: To assess laminin levels in the seminal plasma of infertile and fertile men, and to analyze the correlation of laminin levels with sperm count, age, sperm motility and semen volume. Methods: One hundred and twenty-five recruited men were equally divided into five groups according to their sperm concentration and clinical examination: fertile normozoospermia, oligoasthenozoospermia, non-obstructive azoospermia (NOA), obstructive azoospermia (OA) and congenital bilateral absent vas deferens (CBAVD). The patients' medical history was investigated and patients underwent clinical examination, conventional semen analysis and estimation of seminal plasma laminin by radioimmunoassay. Results: Seminal plasma laminin levels of successive groups were: 2.82 ± 0.62, 2.49 ± 0.44, 1.77 ± 0.56, 1.72 ± 0.76, 1.35 ± 0.63 U/mL, respectively. The fertile normozoospermic group showed the highest concentration compared to all infertile groups with significant differences compared to azoospermic groups (P < 0.05). Testicular contribution was estimated to be approximately one-third of the seminal laminin. Seminal plasma laminin demonstrated significant correlation with sperm concentration (r= 0.460, P < 0.001) and nonsignificant correlation with age (r= 0.021, P= 0.940), sperm motility percentage (r= 0.142, P= 0.615) and semen volume (r= 0.035, P= 0.087). Conclusion: Seminal plasma laminin is derived mostly from prostatic and testicular portions and minimally from the seminal vesicle and vas deferens. Estimating seminal laminin alone is not conclusive in diagnosing different cases of male infertility.

Edited by Aleksander Giwercman
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: azoospermia; basement membrane; congenital bilateral absent vas deferens; laminin; male infertility; semen; seminal plasma; testis

Document Type: Original Article

Affiliations: 1: Andrology Department, Faculty of Medicine, Cairo University, Cairo 12311, Egypt 2: Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo 12311, Egypt 3: Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo 12311, Egypt

Publication date: 2007-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more