Testing for Equality of Standardized Composite Measures of Linkage Disequilibrium

Authors: Hamilton, D. C.; Cole, D. E. C.

Source: Annals of Human Genetics, Volume 72, Number 2, March 2008 , pp. 292-296(5)

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Abstract:

Summary

We described the approximate variance for a composite measure of linkage disequilibrium (LD), which depends only on genotype frequencies and allows for departure from Hardy-Weinberg disequilibrium ( Hamilton et al. 2006). Here we extend this work to allow for inferences about differences in composite LD coefficients, as we illustrate with two examples. Simulations demonstrate consistency of type I error rates under most conditions. Calculations for power and sample size are also given.

Keywords: calcium sensing receptor; composite linkage disequilibrium; disequilibrium; Hardy-Weinberg; inference testing

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1469-1809.2007.00404.x

Affiliations: 1: Department of Laboratory Medicine and Pathobiology, University of Toronto, Room 415, Banting Institute, 100 College Street, Toronto, Ontario, Canada M5G 1L5

Publication date: 2008-03-01