Author: H. Costeff

Source: Annals of Human Genetics, Volume 68, Number 5, September 2004 , pp. 515-520(6)

Publisher: Wiley-Blackwell

Abstract:

Summary

Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959–1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40% of etiologically undiagnosed cases of CP in the community (48% of those born at term and 24% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60% of maturely born hemiplegics, 45% of maturely born spastic diplegics, 32% of premature spastic diplegics and virtually all cases of pure ataxia. About 23% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37% is characterized by a single risk factor, usually perinatal.

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1529-8817.2004.00105.x

Publication date: 2004-09-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Genetics
• By this author: H. Costeff

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers