Author: Kamboh M.I.

Source: Annals of Human Genetics, Volume 68, Number 4, July 2004 , pp. 381-404(24)

Publisher: Wiley-Blackwell

Abstract:

Summary

Late-onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE*4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late-onset AD. However, as the APOE*4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE*4, can modify the risk of AD. Recently, genome-wide linkage or linkage disequilibrium studies on late-onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late-onset AD.

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1529-8817.2004.00110.x

Publication date: 2004-07-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Genetics
• By this author: Kamboh M.I.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers