IngentaConnect Frequency of the SCID gene among Arabian horses in the USA

Authors: Bernoco, D.¹; Bailey, E.²

Source: Animal Genetics, Volume 29, Number 1, February 1998 , pp. 41-42(2)

Abstract:

Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring among Arabian horses. The genetic defect responsible for this disease was recently identified as a 5-basepair deletion in the gene encoding DNA-protein kinase catalytic subunit (DNA-PKcs). Horses with one copy of the gene appear normal, while horses with two copies of the gene manifest the disease. The present report describes a PCR-based test for detection of the gene defect and the results from testing 250 randomly selected Arabian horses. The frequency of SCID gene carriers was 8·4% (21/250). Based on the gene frequency reported here, the authors would expect 0·18% (1 out of 567) of Arabian foals to be affected with SCID based on a random breeding population.

Keywords: immunodeficiency; SCID; hereditary disease; gene defect

Document Type: Research article

DOI: 10.1046/j.1365-2052.1998.00237.x

Affiliations: 1: Stormont Laboratories, Inc., Woodland, CA 95616, USA, 2: M H Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, USA

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