IngentaConnect The impact of alcohol use on depressive symptoms in human immunod...

Abstract:

Aims

To examine the impact of alcohol use on depressive symptoms in human immunodeficiency virus (HIV)-infected patients. Design

Data were collected at 6-month intervals and analyzed to evaluate the association between alcohol dependence and consumption on depressive symptoms using longitudinal mixed-effects regression models controlling for specified covariates. Measurements

The two independent variables were current alcohol dependence assessed using the Composite International Diagnostic Interview (CIDI) and past month consumption (heavy versus not heavy drinking) using a validated calendar-based method. The primary outcome was depressive symptoms as measured by the Center for Epidemiologic Studies Depression Scale (CES-D). Participants

HIV-infected adults with current or past alcohol problems. Findings

Alcohol dependence and heavy alcohol use were significantly associated with higher CES-D scores in unadjusted models. In adjusted analyses, the association of current alcohol dependence persisted [mean difference in CES-D was 3.49 for dependence versus non-dependence; 95% confidence interval (CI): 1.76-5.22]; however, the effect of heavy drinking was no longer statistically significant (mean difference in CES-D was 1.04 for heavy versus not heavy drinking; 95% CI: −0.24-2.32). Conclusions

Alcohol use is associated with more depressive symptoms in HIV-infected patients with alcohol problems. This association remains significant after adjusting for potential confounders only when alcohol use meets the criteria for alcohol dependence.

Keywords: Acquired immunodeficiency syndrome; alcohol drinking; alcoholism; depression; depressive disorder; HIV

Document Type: Research article

DOI: 10.1111/j.1360-0443.2008.02245.x

Affiliations: 1: Divisions of General Medicine and Primary Care and Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, 2: Section of Gastroenterology, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA and

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The impact of alcohol use on depressive symptoms in human immunodeficiency virus-infected patients