Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B
Source: Addiction, Volume 103, Number 4, April 2008 , pp. 681-686(6)
Abstract:Aims To determine the prevalence of hepatitis A, B and C viruses in patients attending a methadone maintenance clinic in New York City. Design Cross-sectional. Setting The Adult Services Clinic of Weill Cornell Medical College, an urban hospital-affiliated methadone program. Participants Former heroin addicted adults (n = 103) on methadone maintenance therapy. Measurements Markers for hepatitis A virus [HAV immunoglobulin M (IgM) and imunoglobulin G (IgG)], hepatitis B [hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb) and hepatitis B core antibody (HBcAb)] and hepatitis C virus (HCVAb). Serum alanine aminotransferase (ALT) and quantitative HCV RNA were also obtained. Qualitative detection of HBV DNA and HCV genotype were obtained in a subset of subjects. Findings More than 40% of subjects had markers for all three viruses. HCVAb was the most prevalent (83.5%), followed by HBcAb (65.0%), HAV IgG (46.1%) and HBsAb (41.1%). Hepatitis C RNA was detected in 70.6% of HCVAb positive subjects. While no subject had HBsAg, HBV DNA was detected in 26.4% of subjects who underwent this measure; all (n = 20) had HBcAb as their only HBV marker. The presence of HBV DNA did not influence ALT. Subjects with HCV RNA had higher ALTs than those without HCV RNA. Conclusions Most methadone-maintained subjects had at least one marker for viral hepatitis, with 41.8% having markers for HAV, HBV and HCV. A quarter of subjects had silent HBV infection, defined as the presence of HBV DNA in the absence of HBsAg. These subjects should be considered infectious and pose a public health risk.
Document Type: Research article
Affiliations: 1: The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, USA, 2: Department of Medicine, Fatebenefratelli Hospital Isola Tiberina, Rome, Italy, 3: Gastroenterology and Hepatology, Weill Cornell Medical College, NY, USA
Publication date: 2008-04-01