Innate immunity in aging: impact on macrophage function

Authors: Julie Plowden; Mary Renshaw-Hoelscher; Carrie Engleman; Jacqueline Katz; Suryaprakash Sambhara

Source: Aging Cell, Volume 3, Number 4, August 2004 , pp. 161-167(7)

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Abstract:

Summary

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as ‘pathogen sensors’ and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

Keywords: aging; cytokines; immunity; inflammation; macrophage; wound healing

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1474-9728.2004.00102.x

Affiliations: 1: Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA

Publication date: 2004-08-01