Purinergic regulation of vascular tone and remodelling
Author: Burnstock, G.
Source: Autonomic & Autacoid Pharmacology, Volume 29, Number 3, July 2009 , pp. 63-72(10)
Abstract:Summary 1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.2 There is dual control of vascular tone by adenosine 5′-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia.3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation.4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.
Document Type: Research article
Publication date: 2009-07-01