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Purinergic regulation of vascular tone and remodelling

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1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.

2 There is dual control of vascular tone by adenosine 5′-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia.

3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation.

4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.

Keywords: adenosine 5′-triphosphate; atherosclerosis; hypertension; pain; purinergic; restenosis

Document Type: Research Article


Publication date: July 1, 2009

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