Purinergic regulation of vascular tone and remodelling

$48.00 plus tax (Refund Policy)

Download / Buy Article:



1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.

2 There is dual control of vascular tone by adenosine 5′-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia.

3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation.

4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.

Keywords: adenosine 5′-triphosphate; atherosclerosis; hypertension; pain; purinergic; restenosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1474-8673.2009.00435.x

Publication date: July 1, 2009

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more