Haemodynamic changes after spinal cord transection are anaesthetic agent dependent
1 To evaluate the effect of high spinal cord transection (SCT), between T4 and T5, on the mean arterial pressure (MAP) and heart rate in animals anaesthetized with different anaesthetic agents: ether (n = 12), 20% urethane, 1.2 g kg−1 (n = 12), 2% tri-bromide-ethanol, 200 mg kg−1 (n = 12); chloral hydrate and urethane, 75 and 525 mg kg−1 respectively (n = 12).
2 In the animals anaesthetized with ether or urethane, SCT caused an immediate major drop in MAP, with hypotension and bradycardia throughout the next 10 min. In the animals anaesthetized with urethane + chloralose or tri-bromide-ethanol, SCT transiently increased MAP with subsequent hypotension and bradycardia.
3 In summary, the haemodynamic changes after complete, high SCT are anaesthetic agent dependent. Further research about the exact mechanisms responsible for these diverse autonomic changes is warranted.
Document Type: Research Article
Affiliations: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Cel Nunes de Melo, 1127 CP 3157 Fortaleza, Ceará 60430 270, Brazil
Publication date: October 1, 2007