Skip to main content

Noradrenaline and angiotensin II modify vascular prostanoid release in fructose-fed hypertensive rats

Buy Article:

$43.00 plus tax (Refund Policy)


A fructose-enriched diet induces hypertension, metabolic alterations and insulin resistance in rats, resembling human metabolic syndrome. Previously, we found that prostanoid production was altered in fructose-fed rats.

This study analysed the effects of incubation with noradrenaline (NA) and angiotensin II (Ang II) on prostanoid release in mesenteric vascular beds from control and fructose-fed rats. Animals which received fructose solution (10% w/v) for 22 weeks showed higher systolic blood pressure and triglyceridaemia.

In controls, NA increased 6-keto-prostaglandin (PG) F1α (prostacyclin metabolite) and thromboxane (TX) production. Ang II increased only TX release. In fructose-fed animals, NA increased 6-keto-PG F1α and TX. PGF2α (vasoconstrictor) was also elevated. Ang II also increased PGF2α and PGE2 levels.

In conclusion, in fructose rats Ang II in vitro stimulates a vasoconstrictor prostanoid not stimulated in controls. This could be related to the observed in vivo blood pressure increase. In fructose-fed animals, NA and Ang II also augment vasodilator prostanoids, suggesting a compensatory mechanism because of long-term hypertension.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: angiotensin II; fructose-fed rats; hypertension; noradrenaline; prostanoids

Document Type: Research Article

Publication date: 2007-10-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more