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Noradrenaline and angiotensin II modify vascular prostanoid release in fructose-fed hypertensive rats

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A fructose-enriched diet induces hypertension, metabolic alterations and insulin resistance in rats, resembling human metabolic syndrome. Previously, we found that prostanoid production was altered in fructose-fed rats.

This study analysed the effects of incubation with noradrenaline (NA) and angiotensin II (Ang II) on prostanoid release in mesenteric vascular beds from control and fructose-fed rats. Animals which received fructose solution (10% w/v) for 22 weeks showed higher systolic blood pressure and triglyceridaemia.

In controls, NA increased 6-keto-prostaglandin (PG) F1α (prostacyclin metabolite) and thromboxane (TX) production. Ang II increased only TX release. In fructose-fed animals, NA increased 6-keto-PG F1α and TX. PGF2α (vasoconstrictor) was also elevated. Ang II also increased PGF2α and PGE2 levels.

In conclusion, in fructose rats Ang II in vitro stimulates a vasoconstrictor prostanoid not stimulated in controls. This could be related to the observed in vivo blood pressure increase. In fructose-fed animals, NA and Ang II also augment vasodilator prostanoids, suggesting a compensatory mechanism because of long-term hypertension.

Keywords: angiotensin II; fructose-fed rats; hypertension; noradrenaline; prostanoids

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1474-8673.2007.00409.x

Publication date: October 1, 2007

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