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Postjunctional α1-adrenoceptors in the vasculature of the pithed mouse are of the α1A-subtype

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Abstract:

Summary

1 The pressor action of noradrenaline and its blockade by selective α1-adrenoceptor antagonists in the pithed mouse were evaluated.

2 Chloroethylclonidine (α1B/D-adrenoceptor alkylating agent) or BMY 7378 (α1D-adrenoceptor antagonist), both at 1 mg kg−1, did not block the increase in blood pressure induced by noradrenaline.

3 5-Methylurapidil (α1A-adrenoceptor antagonist), at 0.1 mg kg−1, displaced the dose–response curve approximately six-fold to the right.

4 The results support the idea that the pithed mouse vasculature express α1A-adrenoceptors and suggest that it is a good model to study the roles of α1-adrenoceptors in gene knockout or overexpression.

Keywords: blood pressure; pithed mouse; α1-adrenoceptor subtypes

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1474-8673.2005.00338.x

Affiliations: 1: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados, Sede Sur, México D.F. 2: Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Ave. de los Barrios#1, Los Reyes Iztacala, Tlalnepantla, Estado de México, 54090, México

Publication date: July 1, 2005

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