IngentaConnect Synapses, Schizophrenia, and Civilization: What Made Homo Sapient

Abstract:

Progress in technology has allowed dynamic research on the development of the human brain that has revolutionized concepts. Particularly, the notions of plasticity, neuronal selection, and the effects of afferent stimuli have entered into thinking about brain development. Here I focus on development from the age of four years to early adulthood, during which a 30 percent reduction in some brain synapses occurs that is out of proportion to changes in neuronal numbers. This corresponds temporally with changes in normal child behavior from the loose-associative, almost schizoid, thinking and art of the four-year-old to the more trained, or disciplined, or acculturated—and restrained—personality of the young adult. I propose that the synaptic changes can best be thought of as a winnowing process likely subject to environmental influences. Acquisition of language and the ability to link linguistic cognition to the plastic development of the brain provide a potentially powerful means of explaining the evolutionally explosive development of human cognition and culture. Schizophrenia, a disease that can be envisioned as representing a derangement of synaptic maturation, may provide an entry into the search for genes controlling the processes mediating the unprecedented development of Homo sapiens over the past 40,000 to 70,000 years. The recently completed mapping of the genome of the chimpanzee provides a new frame of reference that may speed the search.

Keywords: autocatalysis; brain development; cognition; culture; emergence; evolution; genetics of brain function; human brain; plasticity; puberty; religion; schizophrenia; synapses

Document Type: Research article

DOI: 10.1111/j.1467-9744.2007.00864.x

Affiliations: 1: Clinical Professor Emeritus of Pediatrics at Brown University School of Medicine.

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Synapses, Schizophrenia, and Civilization: What Made Homo Sapient?