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One-stage prothrombin time, activated partial thromboplastin time, thrombin time, fibrin degradation product concentration, and antithrombin activity in healthy adult alpacas

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Abstract:

Background:

Alpacas are increasingly presented to veterinarians for evaluation and care. Reports of alpaca reference intervals for one-stage prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), concentration of fibrin degradation products (FDP), and antithrombin (AT) activities are scarce or nonexistent. Objective:

The aim of this study was to determine values for blood coagulation times (PT, aPTT, and TT), FDP concentrations, and AT activities in healthy adult alpacas. Methods:

Of blood samples collected from 35 clinically healthy adult alpacas via jugular venipuncture and placed into sodium citrate and FDP tubes, 29 samples were assayable for coagulation testing. PT, aPTT, and TT were determined by physical (mechanical) clot detection; AT activity was determined using a thrombin-specific chromogenic substrate end-point assay; and FDP concentrations were determined by the slide agglutination method. Results:

Median values and ranges (minimum–maximum) were determined for PT (8.7 seconds, 6.6–11.2 seconds), aPTT (17.3 seconds, 11.9–22.5 seconds), TT (10.2 seconds, 5.4–16.0 seconds), and AT activity (123.3%, 104.8–144.2%). The mean concentration of FDP was <8 μg/mL. Conclusion:

These values for coagulation times, FDP concentration, and AT activity will provide a useful starting point in the diagnostic evaluation of ill adult alpacas.

Keywords: Camelid; Lama pacos; clotting time; coagulation; hemostasis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1939-165X.2011.00312.x

Affiliations: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA

Publication date: June 1, 2011

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