Skip to main content

Estimating the optimal dynamic antipsychotic treatment regime: evidence from the sequential multiple‐assignment randomized Clinical Antipsychotic Trials of Intervention and Effectiveness schizophrenia study

Buy Article:

$43.00 plus tax (Refund Policy)

Summary.  Treatment of schizophrenia is notoriously difficult and typically requires personalized adaption of treatment because of lack of efficacy of treatment, poor adherence or intolerable side effects. The Clinical Antipsychotic Trials in Intervention Effectiveness schizophrenia study is a sequential multiple‐assignment randomized trial comparing the typical antipsychotic medication perphenazine with several newer atypical antipsychotics. The paper describes the marginal structural modelling method for estimating optimal dynamic treatment regimes and applies the approach to this schizophrenia study. Missing data and valid estimation of confidence intervals are also addressed.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: McGill University, Montreal, Canada, and Group Health Research Institute, Seattle, USA 2: McGill University, Montreal, Canada

Publication date: 2012-08-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more