Skip to main content

Analysis of subgroup effects in randomized trials when subgroup membership is missing: application to the second Multicenter Automatic Defibrillator Intervention Trial

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Summary.  We develop and implement a methodology for drawing inference about subgroup effects in a two‐arm randomized trial when subgroup status is known only for a non‐random sample in each of the trial arms. Since the subgroup effects are not point identified from the distribution of the observed data, we show how to compute bounds on these effects by using scientifically plausible assumptions. We characterize the uncertainty of our procedure by using the Bayesian paradigm. The methodology is developed in the context of the second Multicenter Automatic Defibrillator Intervention Trial, which was a randomized trial designed to evaluate the effectiveness of implantable defibrillators on survival.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1467-9876.2010.00759.x

Affiliations: 1: Johns Hopkins Bloomberg School of Public Health, Baltimore, USA 2: Medical University of South Carolina, Charleston, USA 3: Johns Hopkins School of Medicine, Baltimore, USA

Publication date: August 1, 2011

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more