Skip to main content

Generalized monotonic functional mixed models with application to modelling normal tissue complications

Buy Article:

$48.00 plus tax (Refund Policy)

Abstract:

Summary. 

Normal tissue complications are a common side effect of radiation therapy. They are the consequence of the dose of radiation that is received by the normal tissue surrounding the site of the tumour. Within a specified organ each voxel receives a certain dose of radiation, leading to a distribution of doses over the organ. It is often not known what aspect of the dose distribution drives the presence and severity of the complications. A summary measure of the dose distribution can be obtained by integrating a weighting function of dose (w(d)) over the density of dose. For biological reasons the weight function should be monotonic. We propose a generalized monotonic functional mixed model to study the dose effect on a clinical outcome by estimating this weight function non-parametrically by using splines and subject to the monotonicity constraint, while allowing for overdispersion and correlation of multiple obervations within the same subject. We illustrate our method with data from a head and neck cancer study in which the irradiation of the parotid gland results in loss of saliva flow.

Keywords: Dose effect; Functional data; Monotonicity; Non-parametric regression; Normal tissue complications; Overdispersion; Splines

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1467-9876.2007.00606.x

Affiliations: 1: Innovative Analytics, Kalamazoo, USA 2: University of Michigan, Ann Arbor, USA 3: Harvard School of Public Health, Boston, USA

Publication date: April 1, 2008

bpl/rssc/2008/00000057/00000002/art00002
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more