Semiparametric estimation of the duration of immunity from infectious disease time series: influenza as a case-study

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Abstract:

Summary. 

An important epidemiological problem is to estimate the decay through time of immunity following infection. For this purpose, we propose a semiparametric time series epidemic model that is based on the mechanism of the susceptible–infected–recovered–susceptible system to analyse complex time series data. We develop an estimation method for the model. Simulations show that the approach proposed can capture the non-linearity of epidemics as well as estimate the decay of immunity. We apply our approach to influenza in France and the Netherlands and show a rapid decline in immunity following infection, which agrees with recent spatiotemporal analyses.

Keywords: Dynamical models in epidemics; Generalized partially linear single-index model; Immunity; Influenza; Kernel smoother; Susceptible–infected–recovered–susceptible model

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1467-9876.2005.05383.x

Affiliations: 1: National University of Singapore, Singapore 2: University of Cambridge, UK 3: Pennsylvania State University, University Park, USA

Publication date: June 1, 2005

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