Skip to main content

Comparing two measures of creatinine clearance: an application of errors-in-variables and bootstrap techniques

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.


Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.

Keywords: Calibration; Repeated measures; Structural model; True and false positive rates

Document Type: Research Article

Affiliations: 1: Hebrew University, Jerusalem, Israel 2: Rambam Medical Center, Haifa, Israel

Publication date: 1999-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more