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A biomedical application of latent class models with random effects

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Traditional latent class modelling has been used in many biomedical settings. Unfortunately, many of these applications assume that the diagnostic tests are independent given the true disease status, an assumption that is often violated in practice. Qu, Tan and Kutner developed general latent class models with random effects to model the conditional dependence among multiple diagnostic tests. In this paper latent class modelling with random effects is used to estimate the sensitivity and specificity of six screening tests for detecting Chlamydia trachomatis in endocervical specimens from women attending family planning clinics.

Keywords: Chlamydia trachomatis; Conditional independence; Latent class models; Random effects; Sensitivity; Specificity

Document Type: Research Article

Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, USA 2: Cleveland Clinic Foundation, Cleveland, USA

Publication date: April 1, 1998


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